Antibiotic prescribing in remote versus face-to-face consultations for acute respiratory infections in primary care in England: an observational study using target maximum likelihood estimation

Summary Background The COVID-19 pandemic has led to an ongoing increase in the use of remote consultations in general practice in England. Although the evidence is limited, there are concerns that the increase in remote consultations could lead to more antibiotic prescribing. Methods In this cohort study, we used patient-level primary care data from the Clinical Practice Research Datalink to estimate the association between consultation mode (remote versus face-to-face) and antibiotic prescribing in England for acute respiratory infections (ARI) between April 2021 and March 2022. Eligibility criteria were applied at both practice-level and patient-level. 400 practices in England were sampled at random and then 600,000 patients were randomly sampled from the eligible patients (whose sex was recorded). Consultations for acute respiratory infections were identified. All antibiotic prescriptions were included, with the exception of antituberculosis drugs and antileprotic drugs, as identified through chapter 5.1 of the British National Formulary. The CPRD Aurum data was linked to the COVID-19 ONS infection survey by region. All analyses were done at the individual level. Repeated consultations from the same patient within 7 days were grouped together. We used targeted maximum likelihood estimation, a causal machine learning method with adjustment for infection type and patient-level, clinician-level and practice-level factors. Findings There were 45,997 ARI consultations (34,555 unique patients) within the study period, of which 28,127 were remote and 17,870 were face-to-face. For children, 48% of consultations were remote and, for adults, 66% were remote. For children, 42% of remote and 43% of face-to-face consultations led to an antibiotic prescription; the equivalent values for adults were 52% and 42%, respectively. After adjustment with TMLE, adults with a remote consultation had 23% (odds ratio [OR] 1.23, 95% CI: 1.18–1.29) higher chance of being prescribed antibiotics than if they had been seen face-to-face. We found no significant association between consultation mode and antibiotic prescribing in children (OR 1.04 95% CI: 0.98–1.11). Interpretation The higher rates of antibiotic prescribing in remote consultations for adults are cause for concern. We see no significant difference in antibiotic prescribing between consultation mode for children. These findings should inform antimicrobial stewardship activities for health-care professionals and policy makers. Future research should examine differences in guideline-compliance between remote and face-to-face consultations to understand the factors driving antibiotic prescribing in different consultation modes. Funding None.


Introduction
The development of antibiotic resistance is a global public health issue largely fuelled by antibiotic overprescribing.Most antibiotic prescribing in England happens in general practice: 72.1% of total antibiotic prescribing in 2021, 1 of which approximately 20% is inappropriate. 2 This makes general practice an important focus of antibiotic stewardship activities.The digitalisation of general practice was accelerated by the COVID-19 pandemic and has led to an ongoing increase in the use of remote consultations for all ages. 3he full extent of the consequences of this rapid shift towards 'telemedicine' is still unclear and one area of concern is increased antibiotic prescribing in remote consultations.A survey of general practitioners (GPs) in the UK reported that 67% of GPs thought that telehealth has increased their antibiotic prescribing to either a great extent or some extent which corroborates this concern. 4As a GP cannot observe or examine the patient in a remote consultation in the same way as in a face-toface consultation, it has been hypothesised that GPs might increase antibiotic prescribing to be 'on the safe side'. 5ute respiratory infections (ARIs) account for the greatest number of antibiotic prescriptions in UK general practice. 6Remote consultations for ARIs could have a role in reducing spread of infection but overprescription is a particular risk with these conditions.This is because they are often self-limiting and/or commonly caused by viruses rather than bacteria, 7 and because patients with cold or sore throat symptoms often request or even pressure GPs for antibiotics. 8here is limited evidence on the differences in ARI antibiotic prescribing between patients seen face-to-face and those seen remotely-in particular, in a postpandemic setting where close to 50% of consultations are remote.Some observational studies have shown increases in prescribing in remote consultations for certain ARIs 9,10 but other analyses have found a decrease in prescribing in remote consultations 9,11 or no difference. 10,12Additionally, a 2021 meta-analytic systematic review 13 and a 2020 qualitative systematic review 14 of the impact of remote consultation on antibiotic prescribing both proved inconclusive.Additionally, the majority of the relevant primary studies 9,11,12,15 and systematic reviews are at risk of bias due to a failure to control for

Research in context
Evidence before this study Use of remote consultations in general practice has increased rapidly since the onset of the COVID-19 pandemic.Concerns have been raised that antibiotic prescribing rates may be higher in remote compared with face-to-face consultations.Acute respiratory infection (ARI) is the most common reason for an antibiotic prescription in adults making it one of the most important areas of prescription practice for antibiotic use.Empirical studies investigating the differences in antibiotic prescribing rates between online and remote consultations have produced mixed findings, in general and for ARIs specifically.Recent review-type articles on the topicincluding a 2020 qualitative systematic review and a 2021 meta-analytic systematic review-have reported mixed results when comparing online and face-to-face consultations with some showing higher and others lower antibiotic prescribing in remote consultations.Furthermore, many of the studies that were included in the reviews were at risk of bias due to a failure to control for demographic and clinical differences between patients in remote versus face-to-face consultations.

Added value of this study
This is the first England-wide study estimating the difference in antibiotic prescribing between consultations modes since the start of the COVID pandemic, where both remote and face-to-face consultations are now commonly used.It is also the first study in this setting to apply TMLE-doubly robust causal machine learning method.We found that an adult was 23% more likely to be prescribed an antibiotic for an ARI in a remote compared with a face-to-face consultation with a general practitioner in England.There was no evidence for a difference in children.Our findings are based on an analysis of a representative sample of almost 46,000 GP consultations for ARIs in general practice in England and control for patient, clinician-and practice-level factors that are associated with both consultation mode and with antibiotic prescribing.As such, our findings are at a smaller risk of bias from unobserved confounding than the previous research examining this issue and, therefore, represent an important contribution to the evidence base.

Implications of all the available evidence
This study uses rich patient-level data and robust statistical methods and represents an important contribution to the evidence base on antibiotic prescribing in primary care since the start of the COVID pandemic.Taken together with the existing body of evidence on this topic, our results showing higher prescribing in remote consultations are cause for concern.The factors affecting antibiotic prescribing and the interaction with consultation mode are complex and will require further research to unpick.The existing evidence, including this study, have largely focused on prescribing rates, and do not investigate the appropriateness of antibiotics prescribing in remote compared to face-to-face consultations.Further investigation is required to explain the discrepancy in antibiotic prescribing between consultation modes.The growing body of evidence in this area has relevance for future antimicrobial stewardship activities and should be used to inform the ongoing development of antibiotic prescribing guidelines for remote consultations.demographic and clinical differences between patients who are seen remotely and face-to-face.Only one primary study in children used matching to adjust for baseline differences in covariates. 10A more comprehensive understanding of differences in antibiotic prescribing in remote versus face-to-face ARI consultations is required, to inform remote consultation and antibiotic stewardship policy going forward.
In this study, we compare antibiotic prescribing in patients that were seen remotely by a GP for an ARI compared to patients that were seen face-to-face or using a mix of face-to-face and remote consultations.Analyses were conducted separately for adults and children under 16.

Study design and data
We performed a cohort study using person-level data from the Clinical Practice Research Datalink (CPRD) Aurum between January 2018 and July 2022.The study protocol was approved by CPRD's Research Data Governance (protocol number: 21_000357).
CPRD Aurum is a database with routinely collected data from primary care practices that uses EMIS Web®.CPRD contains data for over 40 million patients from 1332 practices in England as of May 2022.Patients are broadly representative of the English population based on age, sex, and deprivation.CPRD also linked their data to the 2015 indices of multiple deprivation (IMD) at the patient-level, and to the 2011 urban-rural classification at the practice-level.The data was linked to the COVID-19 ONS infection survey by region (23 September 2022 release).The COVID-19 ONS infection survey was a large-scale, nationally representative survey that was conducted in the United Kingdom between December 2020 to March 2023 and collected data on the prevalence of COVID-19 infection in the community.This was included to control for changes in the prevalence of COVID-19 during the study period.
We selected the 600,000 patients from 400 practices rather than sample from all practices as we wanted to be able to calculate the proportion of remote consultations per practice.By sampling from 400 practices, we expected to get 10-15% of the list size at each practice and therefore the practice-level variables would be more reliable.This enabled us to check for practices with a very high proportion of remote or face-to-face consultations as this would be a sign of poor coding.Cohort eligibility criteria.
We studied patients registered at general practices that participated in CPRD Aurum.Eligibility criteria were applied at both practice-and patient-level.400 practices in England were sampled at random.Eligible patients were those with acceptable data quality (verified by CPRD); registered at one of the 400 practices at any point between January 2018 and March 2021; recorded as either male or female sex; and eligible for area-level linkage to the index of multiple deprivation (IMD).600,000 patients were then randomly sampled from the eligible patients.Three GP practices were further identified by CPRD as having duplication issues and were excluded from the analysis.

Analysis dataset
Consultations for acute respiratory infections were identified (see Supplemental Materials for codelists).This list was based on previously published lists of read codes. 16There were five subgroups of ARIs: lower respiratory tract infections (LRTI), upper respiratory tract infections (URTI), sinusitis, otitis externa and otitis media as well as COVID.A consultation could be coded as more than one infection subtype.As it is not possible to determine what the primary diagnosis or main reason for consultation is in CPRD, all recorded diagnosis codes for that consultation were used to identify ARIs.
Antibiotics from chapter 5.1 of the British National Formulary (BNF) with the exclusion of antituberculosis drugs (5.1.9)and antileprotic drugs (5.1.10)were included.Antibiotic prescriptions were linked to a consultation either using the observation and problem IDs provided by CPRD, or if they were issued on the same date as an ARI consultation.
Consultations were classified by mode of delivery as either remote (by telephone, video, SMS, and through the internet) or face-to-face (at the GP surgery or at home) consultations based on information in the consultation table for consultation mode or observations recorded during the consultation.Where a consultation's mode was unclear, it was assumed to be face-toface.For a more comprehensive description of these classification methods, readers are referred to 3 where the methodology has been detailed in depth.Only consultations carried out by GPs were included.GPs are likely to be responsible for most of the antibiotic prescribing for ARIs in general practice and have a higher proportion of remote consultations than other health care professionals.There were 67,324 ARI consultations carried out by GPs between 1 April 2021 and 22 March 2022.This period spans the removal of the stay-at-home order to the most recent available data.ARI consultation records for the same patient happening on the same day were grouped together as these were likely to be part of the same consultation (49,451).ARI consultations happening in a 7-day period were grouped together retaining the date of first consultation so that patients were not included multiple times in a short time period.If the consultation mode was the same for all grouped consultations, it was coded as such; if there was a mix of face-to-face and remote consultations, it was recorded as mixed and included in the face-to-face category for the main analysis.If antibiotics were prescribed in any of the grouped consultations, the prescription was retained in the analysis dataset.
No data was imputed for any variables.A very small number of patients (less than 15) that did not have IMD recorded were excluded from the analysis.

Variable selection
To optimise the potential for variable adjustment as well as to ensure the exchangeability at baseline of the treatment arms, as many characteristics as possible were included in the dataset at several covariate levels: consultation-, patient-, clinician-, and practice-level.We adjusted for factors (or their proxies) known to be associated with antibiotic prescribing.These included comorbidities such as asthma or COPD, [17][18][19][20] infection type, health need, rurality, ethnicity, deprivation, 21 region, 22 CCG, 23 clinician job role at practice, 20,24 and overall practice consultation rates based on all patients in the sample.
We also adjusted for variables that were identified through conversations with practising GPs to be associated with either antibiotic prescribing or having a remote consultation.The selection of GPs and the identification of additional variables was not systematic.These included COVID-19 infection in the last 7, 30 or 365 days before the consultation, number of remote or face-to-face consultations in the last 7, 30 or 365 days before the consultation and regional ONS COVID-19 infection prevalence.
All covariates were included in both the treatment and outcome models.See Table S2 for a table of covariates that were included for adults and children.

Key assumptions for causal identification
To identify the treatment effect of consultation mode on antibiotic prescribing, we made the following causal assumptions.The stable unit treatment value assumption, i.e., the treatment status of any individual did not affect the potential outcomes of other individuals.This likely holds as one patient having a remote consultation is unlikely to have an impact on the decision to prescribe antibiotics to a different patient.The second assumption was no unmeasured confounding.In other words, the exposure mechanism and potential outcomes were independent after conditioning on our defined set of covariates.We have minimised the risk of unmeasured confounding through our inclusion of a large selection of relevant patient-, clinician-and practice-level factors that could be linked to both exposure (consultation modality) and outcome (antibiotic prescribing).Thirdly, we assumed positivity, i.e., within strata of the set of covariates, all consultations had a nonzero probability of receiving either exposure condition.By design, only patients with a respiratory infection were included and those can be seen both remotely or face-to-face unlike consultations for other purposes such as vaccinations or wound management.We checked minimum and maximum of the propensity scores from the treatment model for violations of the positivity assumption.
We defined the statistical target parameters as the average treatment effect (ATE) and the odds ratio (OR).

Validation of exchangeability assumption
The standardised mean difference (SMD) was used to assess how similar the distribution of covariates was between remote and face-to-face consultations.A 10% difference was considered large enough to be noteworthy.For statistical disclosure reasons, summary statistics were suppressed in groups with fewer than 10 consultations.

Statistical analysis
The exposure is a binary consultation mode variable (remote codes as 1 and face-to-face/mixed as 0) and the outcome is a binary antibiotic prescription variable (antibiotics prescribed coded as 1/antibiotics not prescribed coded as 0).
We used targeted maximum likelihood estimation (TMLE) to estimate the difference in prescribing rates between patients seen remotely and those seen face-toface.TMLE is a semi-parametric approach used to estimate causal effects in observational data.TMLE is often referred to as a causal machine learning method as it combines elements of machine learning and causal inference.First it creates initial estimates of the treatment and outcome models.Through the construction of a "clever covariate," which is a function of the treatment, outcome, and propensity score (the probability of treatment assignment given a set of observed covariates), TMLE refines the initial estimate of the causal effect optimising the bias-variance trade-off and estimating the statistical target parameters of interest, in this study the ATE and OR.This double robustness property of TMLE provides protection against potential model misspecifications, thus offering reliable causal effect estimation.TMLE relies on cross-validation to minimise overfitting.When used in combination with a superlearner, it can handle high-dimensional data, which makes it a powerful tool to estimate causal effects.
We used 10-fold cross-validation.We clustered the cross-validation by GP practice so that all observations from the same practice would be within the same crossvalidation fold, accounting for intra-practice correlations.In addition to this, we clustered at the individual level in the relevant models comprising the ensemble model, to account for patients appearing multiple times in the data.To ensure consistent prevalence of the binary outcome across cross-validation folds, stratification was performed based on the outcome variable (see Supplemental Materials S3 for more details).
We included a range of models with different strengths in the superlearner, following best practice guidelines based on our data (see Supplemental Materials S3 for more details).Logistic model; a Generalised Additive Model to allow flexibility in capturing nonlinear relationships without a priori specification of the functional form; Random Forest and XGBoost, both tree-based machine learning methods to capture complex interactions and identify key features; Multivariate Adaptive Regression Splines (MARS) model as it can use basis functions (like splines) to model nonlinear relationships; and a lasso net logistic model helped in feature selection by penalising less important variables and reducing them to zero, thus improving model sparsity.Together, these models formed a comprehensive ensemble capturing a range of potential data structures and relationships.Parameter tuning details can be found in Supplemental Materials S3.Using a discrete super learner-which compares the ensemble model with the individual learners-to pick the final model was not computationally feasible.We used non-negative linear least squares as the metalearner for the ensemble model, which is a proven strategy for optimally combining these diverse learners.As this has been proven to perform at least as well as any individual model asymptotically, we considered this a reasonable simplification.The analysis was carried out using R 4.0.2 using sl3 and tmle3 for the modelling.
We reran the models without the mixed consultations that were included in the face-to-face group in the main analysis.

Role of the funding source
No external funding was received.

Results
There were 45,997 consultations for ARIs (34,555 unique patients), of which 61% (28,127) were remote and 39% (17,870) face-to-face.For children, 48% of consultations were remote whereas for adults 66% were remote.Antibiotics were prescribed in 48% of all consultations for adults, and in 52% of remote and 42% of face-to-face consultations.For children, 43% of all consultations led to antibiotic prescriptions with 42% in remote and 43% in face-to-face consultations (Table 1).The median age was 4 in children (0-16) and 49 for adults (16+).In children, 52% of consultations were male compared to only 38% in adults.Ethnicity was missing for a higher proportion of consultations for children than for adults.Adult consultations were evenly distributed across the IMD quintiles but there was a slight over-representation of child consultations in the most deprived IMD quintile (Table 1).
Most consultations were only associated with one infection type (97.5% adults and 97.4% children).The proportion of consultations only associated with one infection was marginally higher in face-to-face compared to remote consultations for both adults and children (2.9% versus 2.3% for adults and 2.6% versus 3.5% for children).Regardless of the type of infection, adults had a higher proportion of remote consultations compared to children.For a URTI, 71% of adults were seen remotely compared with just 53% of children (Figure S1).The most common ARI type for both adults and children was URTI (49.8% and 70.0% of all diagnoses respectively) but the frequency of some infection types differed substantially between adults and children, notably LRTI being high in adults but low in children (14.3% and 5.8% respectively) and otitis media being the opposite (2.8% in adults and 10.1% in children) (Fig. 1A and B).LRTI and otitis media had the highest antibiotic prescribing rates within the study (LRTI: 82.6% adults and 78.9% children; Otitis media: 73.2% adults and 84.3% children) so the prevalence of these infections will highly influence baseline prescribing rates.Antibiotics were more commonly prescribed for adults with URTIs in remote rather than face-to-face consultations (53.3% compared to 46.1%) whereas there was very little difference in prescribing rates for children (39.6% compared to 37.9%).Antibiotics were more often prescribed in remote consultations for COVID infection for both adults (17.5% versus 7.8%) and children (15.0%versuss 2.7%) (Fig. 1C and D).
There were some differences in the baseline characteristics of patients having remote compared with face-to-face consultations (Table 1, Fig. 2).For both adults and children, consultations were more likely to be remote when related to a URTI or in an urban practice and more likely to be face-to-face when related to an otitis media diagnosis or with a GP registrar.The number of previous ARI face-to-face consultations in the last year was also associated with being seen face-to-face.
The minimum and the maximum propensity scores were 0.037 and 0.944, respectively, for children; and 0.039 and 0.962, respectively, for adults which suggests the positivity assumption is reasonable.
The results without mixed mode consultations are consistent with the main analysis (Table S4).

Discussion
Using data from almost 46,000 GP consultations for ARIs in general practice in England we estimated differences in antibiotic prescribing between remote and face-to-face ARI consultations.After adjusting for a variety of factors, we found that an adult who had a remote consultation was 23% more likely to be prescribed antibiotics compared to if they had had a face-to-face consultation.In contrast, we found no evidence of an association between consultation mode and antibiotic prescribing in children.
The overall antibiotic prescribing rates by infection type are broadly similar to previously published estimates. 25,26However, this study adds new insight on the use of remote consultation for different infection sub-groups.Remote consultations are used for all types of ARIs, but there is variation in the proportion of remote consultations by infection type.Patients are most likely to be seen remotely for sinusitis, and least likely to be seen remotely for otitis media.As the need for antibiotics also differs by infection type, the unadjusted baseline prescribing rate for remote and face-to-face consultations are different.This shows the importance of interpreting unadjusted estimates cautiously.Our finding that antibiotics are more likely to be prescribed to adults in remote rather than face to face consultations represents an important contribution to the field.The existing evidence from observational studies on remote consultations and antibiotic prescribing is mixed [9][10][11][12] but our result is consistent with survey evidence showing 67% of UK GPs believe that telehealth has increased their antibiotic prescribing. 4We applied TMLE to a large patient-level dataset with a wide range of variables including the infection type.The rich data means that we can control for more demographic, socioeconomic and clinical variables than most studies and the machine learning methods allow for more complex non-linear relationships between variables to be accounted for.Therefore, this provides the strongest evidence yet that antibiotic prescribing is higher in remote ARI consultations compared to face-to-face for adults.
We do not observe a difference by consultation mode in antibiotic prescribing for children.This could mean that there is no difference or that we were unable to detect it.Previous studies have found a difference in children but in different settings. 15The decision to prescribe depends on many factors including comorbidities and acuity.As children often have few comorbidities, acuity and other unobserved factors would be more important when prescribing antibiotics to children so there is more potential for unobserved confounding.
Including both adults and children in the same study provides us with a unique opportunity to compare results from the same practices during the same time period.A potential explanation for why we see a difference in adults but not in children could be that GPs are more risk averse when consulting with children and prefer to bring them in for a face-to-face consultation before prescribing.We do observe a higher proportion of both face-to-face and mixed consultations in children.
The factors affecting antibiotic prescribing for ARIs, and the interaction with consultation mode are complex and will require further research to disentangle.Both patients and GPs might behave differently in a face-toface compared with a remote consultation.Total triage (patients are remotely assessed before booking into a consultation) should ensure that patients have the right type of consultation for their concern, but this system is not used by all practices, and is not perfect, especially when there is high demand for appointments.Patients may exert particular pressure on GPs in certain types of appointments.Clinical examinations, which may help to determine the need for antibiotics-such as listening to a chest or looking in an ear-are not possible in a remote consultation, which may influence prescribing.Increased GP workload has also been associated with increased prescribing of broad-spectrum antibiotics 27 and consultations for ARIs where antibiotics are prescribed have been found to be shorter, which could also influence prescribing. 28here are implications for both antibiotic prescribing and the use of remote consultations.Increased prescribing in adults could have a substantial impact on the UK's commitment to reduce antibiotic prescribing by 15% by 2024, given ∼70% of antibiotics prescribing happens in primary care and that ARIs are the most common condition that antibiotics are prescribed for. 1,29ntibiotic prescribing declined from 2015 to 2019 but data from the pandemic is harder to interpret. 30Both patients and health care professionals have an important role to play in ensuring sustainable use of antibiotics.Clinical guidelines should be adapted to make sure antibiotic prescribing advice for GPs factors in remote consultations.For example, many clinical risk scores used to guide antibiotic prescribing were developed for use in face-to-face consultations, so it may be necessary for separate risk scores to be developed for use in remote consultations.It is also important to consider that remote consultations have the positive externality of not requiring unwell patients to travel to the GP surgery thereby reducing the spread of respiratory infections.
There should be continued focus on educating the public on the importance of responsible use of antibiotics.Some antimicrobial stewardship activities such as the Treat Antibiotics Responsibly, Guidance, Education and Tools initiative have been adapted to work better for both prescribers and patients in remote consultations. 1 The risks and benefits of remote consultations in general practice are not fully understood.Further research is required to understand differences in quality of care and outcomes between remote and face-to-face consultations across a range of clinical scenarios.This study raises a concern that antibiotic prescribing rates for adults are significantly higher in remote consultations, but we do not know whether this is clinically appropriate.More work is needed to explore the appropriateness of antibiotic prescriptions across consultation modes and in different clinical contexts.That work may in turn inform our approaches to triage, by aiding understanding of clinical indications for directing patients to one consultation type over another.More research is required to investigate if any difference in antibiotic prescribing rates based on consultation mode varies across demographic groups (for example, by sex/gender or socioeconomic status).
Further quantitative analysis is needed to explore whether our findings hold true for other prescribers.This is especially important given the rapid rise in numbers of nurse practitioners, pharmacists and paramedics working in general practice.Qualitative investigation of the issue, including speaking to clinicians and patients, and observing ARI consultations to explore how antibiotic prescribing plays out in practice in remote versus face-to-face environments is also needed.
We have used a large patient-level dataset that is representative of the English population.We controlled for patient-, clinician-and practice-level factors known to be associated with antibiotic prescribing using a doublyrobust causal machine learning method.In addition, the way we classified consultations into remote, mixed and face-to-face and then grouped mixed and face-to-face consultations together, more accurately reflects the way consultations take place in general practice in England rather than using only face-to-face consultations as the comparator.
Although we included a wide range of factors, there may still be unobserved confounding, such as urgency, acuity, or staffing levels, that could influence both consultation mode and antibiotic prescribing, but we are unable to measure them in this study.This could impact the results but it is unlikely to fully remove the relationship we observe between consultation mode and antibiotic prescribing in adults.
The practices that participate in CPRD Aurum could be different to those that do not.We further limited inclusion in the study to only practices that have consented to take part in further data linkage (IMD and urban rurural index in this study).At patient level, only patients that had valid postcode recorded were included as this was necessary for the linkage.Patients in CPRD Aurum have been shown to be representative of the broader English population but it is not possible to check to what extent, if at all, the exclusion criteria applied at the practice and patient level would change this.
We are unlikely to capture all ARIs due to poor clinical coding-some studies found that only 69% of antibiotics prescribed could be linked to a specific part of the body and/or clinical condition. 31A further limitation of the ARI coding is that there is no distinction between primary and secondary diagnoses in CPRD Aurum.There could be a difference in the accuracy and completeness of coding (both of symptoms and antibiotic prescribing) as well as frequency of primary versus secondary diagnoses between remote and face-toface consultations.This could lead to bias if poor coding was applied to a greater extent to either consultation mode.We only included ARI GP consultations, not other potential prescribers, and we did not differentiate between acute and delayed prescriptions or whether the prescriptions were guideline compliant.
Our results are concerning because of the potential implications for antibiotic consumption and resistance.Further research is needed to understand the causes of increased antibiotic prescribing in remote consultations, and to determine whether the observed increase is appropriate.
On a broader level, the effect of increased remote consulting in general practice needs to be considered in the round.While the rapid introduction of remote consultations was a great success in the sense that it allowed general practice to keep functioning in the first few months of the pandemic, there may be unintended consequences that follow.Careful and thorough evaluation of interventions takes on an even greater importance when changes are instituted rapidly, as was the case with the accelerated rollout of remote consultations.

Fig. 1 :Fig. 2 :
Fig. 1: Breakdown of infection type codes (% of total) (A & B) and proportion of consultations leading to an antibiotic prescription by consultation mode and infection.